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Simultaneous Estimation of Ramipril and Telmisartan in Tablet Dosage Form by Spectrophotometry


Popat B. Mohite, Ramdas B. Pandhare, Vaidhun H. Bhaskar

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Keywords

Ramipril, Telmisartan, Multicomponant Method, Graphical Absorbance Method

Abstract

Two simple, accurate, sensitive and specific methods are described for the simultaneous determination of Ramipril and Telmisartan in binary mixture. The method based on UVspectrophotometric determination of two drugs, Method A is by using multicomponant method. It involves absorbance measurement at 205.0 nm(λmax of Ramipril) and 291.0 nm (λmax of Telmisartan) in 0.2M H2SO4;. Beer’s law is obeyed in the concentration range of 5-40 μg mL-1 for Ramipril and 2-20 μg mL-1 for Telmisartan. Method B is graphical absorbance method which is based on measurement of absorbance of Ramipril and Telmisartan at 222.0nm (iso-absorptive point of Ramipril and Telmisartan) and 291.0 nm (λmax of Telmisartan) Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.