Synthesis, Characterization and Biological Activity of new Pyran Derivatives of 8-Hydroxyquinoline

Mohamed Rbaa, Omar Bazdi, Younes Lakhrissi, Khadija Ounine, Brahim Lakhrissi*

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Synthesis, Quinolinol, Characterization, Antibacterial activity, Bacterial strains.


We have synthesized a new pyran derivatives based on 8-hydroxyquinoline such as 2-Amino-4-phenyl-4H-pyrano [3,2-h] quinoline-3-carbonitrile (QP-H), 2-Amino-4-(4chlorophenyl)-4H-pyrano-[3,2-h] quinoline-3-carbonitrile (QP-Cl), 2-Amino-4-(4methoxyphenyl)-4H-pyrano-[3,2-h]quinoline-3-carbonitrile (QP-OCH3) and 2-Amino-4-(4nitrophenyl)-4H-pyrano[3,2-h]quinoline-3-carbonitrile (QP-NO2). All the synthesized compounds were identified by elemental analysis data, IR, 1 H and 13 C NMR spectroscopy and were evaluated and screened “in vitro” by the disk diffusion technique against Grampositive and Gram-negative bacterial strains (E. coli (ATCC35218), S. aureus (ATCC29213), V. parahaemolyticus (ATCC17802), and P. aeruginosa (ATCC27853)). The preliminary screening results showed that all the compounds displayed a potential antibacterial activity against all the tested four Gram bacteria. The results revealed that most of the tested compounds have a very good antibacterial activity compared to the standard antibiotic (Penicillin G).