Synthesis & Characterization of Heterocyclic Amide Derivative via Ugi Reaction

Abstract

Synthesis of heterocyclic amid derivative (cyclohexanecarbox-amide) by the reacting
four-compound [Formaldehyde], [N-(phenethyl)formamide], [Cyclohexanecarboxylic
acid], and [Creatinine] as amine source. This reaction is practical extension of (Ugi
reaction). The derivatives have been performed with other catalytic agents under temp
(-10°C) and the organic synthesis was monitories by TLC [thin layer chromatography]
and the formation of final compound proofed by Nuclear Magnetic Resonance Spectra
[
1HNMR] [13CNMR] BRUKER (500MHz, CDL3), (125MHz, CDL3 and Infra-Red spectra [FTIR] (shimadzu).