Application of Differential Scanning Calorimetry and Fourier Transform Infrared Spectroscopy to the Study of Metoprolol-Excipient and Lisinopril-Excipient Compatibility

Abstract

Studies of pharmaceutical drug/active pharmaceutical ingredient (API) compatibility represent an important phase in the design or development of new formulation stage and drug delivery systems. Excipients in the formulations are influenced by the chemical nature, stability, manufacturability, drug bioavailability or delivery of the drug to the patient. Differential scanning calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR) were used as an analytical screening technique for defining the conformity, quality, ability, compatibility of metoprolol and lisinopril with some recently employed pharmaceutical excipients.