Quantitative Determination of Chemical Markers in Poly Herbal Cough Syrups: A Systemic Review

Abstract

Polyherbal medicines are not a simple task as many traits impact the biological
efficacy and reproducible therapeutic effect. Polyherbal Cough preparations used for its
antitussive activity from an ancient time. Pharmacological properties of an herbal
formulation depend on Phyto constituents present. An overview covering various
techniques employed in extraction and characterization of different herbal cough syrups.
An overview covering various analytical techniques employed in quantification of markers
in different marketed herbal cough syrups. The regulatory approvals to ascertain
consistent chemical profile and biological activity of future drug candidate include
reproducibility by repetitive testing using different batches to control batch-to-batch
variation and development of standard assay markers. New approaches enable analysts to
separate and determine biomarkers in complex mixtures of herbal formulations. Various
marketed herbal cough syrups like Adulsa syrup, Honitus syrup, Herbal cough syrup,
Linkus Syrup, Poly herbal Cough syrup, Echinopsechinatus Roxb. Herbal Cough Syrup and
Zeal syrup are studied for their plant part used therapeutic activity and phytochemical
quantification.