“STUDY OF PRO-BRAIN NATRIURETIC PEPTIDE LEVELS IN PATIENTS OF ACUTE RESPIRATORY DISTRESS SYNDROME”
DOI:
https://doi.org/10.53555/zhw2xf83Keywords:
Acute Respiratory Distress Syndrome, Pro-Brain Natriuretic Peptide, ARDS severity, ventilatory support, biomarker, patient outcomesAbstract
Background: Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition with high morbidity and mortality. Brain Natriuretic Peptide (BNP) and its precursor, Pro-BNP, have been explored as potential biomarkers for predicting outcomes in ARDS, but their clinical significance remains unclear.
Methods: This single-center, prospective study included 96 ARDS patients. Pro-BNP levels were measured at admission and after 72 hours. Patients were categorized based on ARDS severity, ventilatory support, ICU stay duration, and outcomes. Statistical analysis assessed the correlation between Pro-BNP levels and disease severity, oxygenation status (PaO₂/FiO₂ ratio), and prognosis.
Results: The study observed significantly elevated Pro-BNP levels at admission, with a marked decrease at 72 hours (p < 0.001), except in non-survivors, where levels increased. Improved PaO₂/FiO₂ ratios were noted over 72 hours, indicating better oxygenation. Higher Pro-BNP levels correlated with severe ARDS, prolonged ICU stays, and increased mortality (p < 0.0001). The overall mortality rate was 14.58%, with 85.42% of patients discharged.
Conclusion: Pro-BNP levels serve as a valuable prognostic marker in ARDS, correlating with disease severity and outcomes. Its decreasing trend over time suggests clinical improvement, while persistently high levels indicate poor prognosis.
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