An Eco-Friendly And Highly Effective Approach: One-Pot Synthesis Of Pyranopyrazole Derivatives Using A Multicomponent Strategy
DOI:
https://doi.org/10.53555/bpekq573Keywords:
Green synthesis; Ecofriendly solvent; Pyranopyrazoles; Antifungal; AntibacterialAbstract
A novel, multi-faceted approach for synthesizing pyranopyrazole derivatives featuring a thioether linkage has been devised, notably excluding the use of catalysts to promote environmental sustainability. This innovative technique avoids reliance on toxic solvents and catalysts, employs a straightforward purification process, and consistently delivers near-complete yields to minimize impurities. Additionally, an in-depth evaluation of the antifungal and antibacterial properties of all synthesized compounds was conducted. Certain compounds, specifically AG19 and AG20, exhibited exceptional antibacterial efficacy, while others, namely AG15 and AG16, demonstrated superior antifungal activity compared to standard treatments. These results strongly suggest that the identified active compounds hold significant promise as a robust platform for advancing the development of new antioxidant and antibacterial therapeutics in future research endeavors.
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