Comparison of FT-NIR and HPLC for Green Approach to Assay Cefixime in Its Pharmaceutical Capsules
Keywords:
cefixime capsules, FT-NIR transmission, GAC (green analytical chemistry), HPLC assay, PAT (process analytical technology), validation; PLS modelAbstract
Near-infrared spectroscopy (NIRS) has become an analytical technique of great interest
for the pharmaceutical industry, particularly as a greener analytical technique. In this
paper a calibration model for cefixime in the capsules pharmaceutical dosage form was
built by utilizing chemometric processing based mainly on a partial least square
regression fit to assay the material using NIR technique. The results obtained by NIR
spectroscopy were compared with the compendial HPLC method for cefixime capsules
produced by USP. The present study showed that cefixime capsules can be individually
analyzed by NIR with high accuracy. This proposed technique realizes a lot of green
analytical aspects in developing eco-friendly analytical method