Direct Determination of Captopril Using Electrogenerated Halogens for Pharmaceuticals Quality Control
Keywords:
Coulometric titration; Electrogenerated halogens; Pharmaceutical analysis; Captopril.Abstract
Simple, rapid, accurate and inexpensive coulometric method for captopril determination
using electrochemically generated halogens as titrants is proposed. The stoichiometric
coefficients of the reactions are 1:3, 1:3 and 1:1, for chlorine, bromine and iodine, respectively.
Procedure for direct determination of captopril in pharmaceuticals has been developed with an
RSD of 0.01-0.04. The data were compared with the results obtained by anodic adsorptive
stripping voltammetry. Good agreement of the data obtained allows to propose coulometric
determination for pharmaceuticals quality control