Synthesis and identification of some quinazolines and 1,3-oxazepines derived from thiosemicarbazone and evaluation of its bacterial activity

Abstract

Thiosemicarbazide derivatives (A1-A2) were synthesized by the reaction of (pbromo aniline and p-amino acetophenone ) respectively withcarbondisulfide (CS2) /
hydrazine hydrate .Compounds (A1-A2) were allowed to react with aromatic benzaldehyde
(p-N,N-dimethyl amino , p-chloro and p-hydroxybenzaldehyde) to form compounds of
thiosemicarbazone (A3-A8) using fusion method.Quinazoline compounds (A9-A14) were also
formed by reaction of (A3-A8) with anthranilic acid using fusion method . Compounds (A3-
A8) were also reacted with maleic anhydride to form 1,3- oxazepine compounds (A15-A20) by
fusion method. The prepaered compounds were identified by ( I.R ,1H.NMR, 13C.NMR and
melting points. ) .