Salivary Cystatin C as a Biochemical Marker for Chronic Renal Failure

Abstract

A case control study was conducted on 49 subjects 29 of them with chronic renal
disease and 20 subjects as control with age range between (45-75) years were
investigated to determine the correlation of salivary and serum cystatin, urea and
creatinine to assess their significance in the diagnoses of patients with chronic renal
disease. The results indicated that the level of salivary cystatin was significantly (P ≤
0.05) elevated in chronic renal disease (292.517±37.19 ng/ml) as compared to control
(144.45±22.963 ng/ml). The level of serum cystatin was significantly (P ≤ 0.05) elevated
in chronic renal disease (498.414±59.091 ng/ml) as compared to control
(391.60±49.488ng/ml). The level of serum creatinine was significantly (P ≤ 0.05)
elevated in chronic renal disease (4.369±0.799 mg/dl) as compared to control (1.007±
0.180 mg/dl). The level of urea was significantly (P ≤ 0.05) elevated in chronic renal
disease (56.138±5.908 mg/dl) as compared to control (31.80 ± 5.176 mg/dl). From all
the above results, we can conclude that salivary cystatin can be considered as a better
biochemical marker for renal function compared to serum cystatin in chronic renal
disease.