Synthesis And Biological Screening of Some New N-Substituted Thiocarbamido 2-Chlorophenothiazines
Keywords:
Substituted 2-chlorophenothiazine, Antibacterial activity, Antifungal activity, Antioxidant activityAbstract
A series of synthesis of new N- substituted thiocarbamido derivatives of 2-chlorophenothiazines using various substituted thiourea and synthesized compounds were characterized by IR, 1H NMR, and Mass spectra. Final compounds [2(a-f)] have been evaluated for their antibacterial and antioxidant screening. Some of the compounds showed promising antimicrobial, antifungal and antioxidant activities.
References
The Art of Drug Synthesis, edited by Johnson, D. S.; Li, J. J. Published by John Wiley & Sons, Inc., Hoboken, New Jersey, 2007.
Swarnkar, P. K.; Kriplani, P.; Gupta, G. N.; Ojha, K.G., E-J. Chem., 2007, 4, 14-20.
Havaldar, F. H.; Khatri, N. K., Indian J. Heterocyclic Chem., 2006, 16, 87-88.
Tandon, V. K.; Maurya, H. K.; Tripathi, A.; ShivaKeshava, G.B.; Shukla, P. K.; Srivastava, P.; Panda, D., Eur. J. Med. Chem., 2009, 44, 1086-1092.
Mohamed, F. A.; Mohamed, H. A.; Hussein, S. A.; Ahmed, S. A. A., J. Pharm. Biomed. Analysis., 2005, 39, 139–146.
Wen, B.; Zhou, M., Chemico-Biol. Interact., 2009, 181, 220–226.
Sadanandam, Y. S.; Shetty, M. M.; Rao, A. B.; Rambabu, Y., Eur. J. Med. Chem., 2009, 44, 197-202.
Rajasekaran, A.; Thampi, P. P., Acta Pharm. Turcica., 2003, 45, 227-232.
Sami, S. M.; Dorr, R. T.; Alberts, D.S.; Solyom, A.M.; W.A. Remers, W.A., J. Med. Chem., 2000 43, 3067–3073.
Wang, J. J.; Liu, T. Y.; Yin, P. H.; Wu, C. W.; Chern, Y. T.; Chi, C.W., Anticancer Res., 2000, 20, 3067–3073.
Kadu, S. S.; Korpe, G. V., Rasayan J. Chem., 2016, 9(1), 40-43.
Tayade, D. T., Orient J. Chem., 1997, 13(3), 37620.
Aswale, S. S.; Aswale, S. R.; Ramteke, B.; Tayade, D., International Journal of Research in Biosciences, 2014, 1(2), 7-13.
Tayade, D. T.; Waghmare, S. A., Am. J. Pharm. Tech. Res., 2016, 6(3), 2249-3387.
Tayade, D. T.; Waghmare, J. S.; Patil, S. U., Asian Journal of Chemistry, 2007, 19(1), 443.
Tayade, D. T.; Gobre, A. V., Ind. J. pharm. Sci. res., 2014, 4(2), 122-123.
Tayade, D. T., Lunge, M. S., Elixir Int. Journal, 2015, 89, 36820-36823.
Tayade, D. T.; Wadekar, A. B., Int. J. App. Res., 2015, 1(13), 640-642.
Tayade, D. T.; Wadekar, A.B., J. Med. Chem. Drug Disc., 2016, 1(2), 1-5.
Tayade, D. T.; Tayade, K. D.; Wadekar, A. B., J. Med. Chem. Drug Disc., 2016, 1(2), 6-10.
Tayade, D. T.; Wadekar, A. B., World J. Pharm. Sci., 2016, 2321-3086.
Tayade, G. D.; Waghmare, S. A.; Naik A. B.; Tayade, D. T., J. Med. Chem. Drug Disc., 2016, 1(2), 14-28.
Tayade, D. T.;.Thombare, R. D., J. Med. Chem. Drug Disc., 2016, 1(2), 23-127.
Tayade, D. T.; Ingole, S. P., Eur. J. Pharm. Med. Res., 2016, 3(7).
Tayade, D. T.; Wadekar, A. B., Palagia research library, 2016, 7(1), 20-23.
Tayade, D. T.; Kale, P. R., Int. pharm. Pharm. Res., 2016, 6(3).
Tayade D. T.; Wadekar, A. B., Indo Am. J. Pharm. Sci., 2016, 3(7), 693-705.
Cruickshank, R.; Duguid,J. P.; Marion, B. P., Medicinal Microbiology, 1975, 20, 196–202.
Collins, A. H., Microbiological Methods, second ed. Butterworth, London, 1976
Chatrabhuji, P. M.; Vyas, K. B.; Nimavat, K. S.; Undavia, N. K., Organic Chemistry, 2013, 54, 12781