Seroprevalence Of Cytomegalovirus Infection In Women With Bad Obstetric History Visiting A Tertiary Care Hospital In Central India
Keywords:
Cytomegalovirus, Bad Obstetric History, Seroprevalence, ELISAAbstract
Background: Human Cytomegalovirus (CMV) otherwise known as Human Herpes virus 5; is a member of herpes viridae family. It is a ubiquitous agent and one of the important causes of intrauterine infections. The infection is usually asymptomatic in adults. Prenatal infections of CMV have severe fetal consequences.
Aims & Objective: To detect seroprevalence of CMV in pregnant women with Bad Obstetric History.
Materials & Method: The present retrospective study was carried out from 1st January 2018 to 31st Dec. 2020 in the Serology section of the department of Microbiology of a teaching tertiary care hospital located in central India. The blood samples received from 92 women with Bad Obstetric History were tested for CMV IgG & IgM antibodies by ELISA method (Calbiotech Inc., USA).
Results & Discussion: Out of 92 serum samples tested, 70.6% patients were IgG positive and 8.6% were IgM positive. Among these 8.6% patients were found to be positive for both IgG & IgM antibodies. Several studies have also quoted the seroprevalence of CMV ranging from 9% to 80-90% in different regions from India and abroad. It has mainly shown variations based on geographic, socioeconomic, and ethnic backgrounds and on child‐rearing practices such as breast‐feeding and use of day‐care facilities.
Conclusions: The result indicates moderate prevalence of CMV in the women with Bad Obstetric History. It would be beneficial to screen women of reproductive age group for CMV IgG & IgM antibodies. It would help us to provide appropriate therapy and prevent intrauterine death or congenital fetal abnormalities.
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