Seroprevalence Of Cytomegalovirus Infection In Women With Bad Obstetric History Visiting A Tertiary Care Hospital In Central India

Seroprevalence Of Cytomegalovirus Infection In Women With Bad Obstetric History Visiting A Tertiary Care Hospital In Central India

Authors

  • Dr Amit Kumar
  • Dr Bharat singh
  • Dr Trupti Bajpai
  • Manish Chauhan
  • Sonu Maity

Keywords:

Cytomegalovirus, Bad Obstetric History, Seroprevalence, ELISA

Abstract

Background: Human Cytomegalovirus (CMV) otherwise known as Human Herpes virus 5; is a member of herpes viridae family. It is a ubiquitous agent and one of the important causes of intrauterine infections. The infection is usually asymptomatic in adults. Prenatal infections of CMV have severe fetal consequences.

Aims & Objective: To detect seroprevalence of CMV in pregnant women with Bad Obstetric History.

Materials & Method: The present retrospective study was carried out from 1st January 2018 to 31st Dec. 2020 in the Serology section of the department of Microbiology of a teaching tertiary care hospital located in central India. The blood samples received from 92 women with Bad Obstetric History were tested for CMV IgG & IgM antibodies by ELISA method (Calbiotech Inc., USA).

Results & Discussion: Out of 92 serum samples tested, 70.6% patients were IgG positive and 8.6% were IgM positive. Among these 8.6% patients were found to be positive for both IgG & IgM antibodies. Several studies have also quoted the seroprevalence of CMV ranging from 9% to 80-90% in different regions from India and abroad. It has mainly shown variations based on geographic, socioeconomic, and ethnic backgrounds and on child‐rearing practices such as breast‐feeding and use of day‐care facilities.

Conclusions: The result indicates moderate prevalence of CMV in the women with Bad Obstetric History. It would be beneficial to screen women of reproductive age group for CMV IgG & IgM antibodies. It would help us to provide appropriate therapy and prevent intrauterine death or congenital fetal abnormalities.

Author Biographies

Dr Amit Kumar

Associate professor Department of Microbiology, Zydus Medical College Dahod Gujrat

Dr Bharat singh

Assistant professor, MGM Medical college Indore

Dr Trupti Bajpai

Assistant professor Department of Microbiology, Sri Aurobindo Medical College & PG Institute Indore M.P.

Manish Chauhan

Tutor Department of Microbiology, Sri Aurobindo Medical College & PG Institute Indore M.P

Sonu Maity

Tutor Department of Microbiology, Sri Aurobindo Medical College & PG Institute Indore M.P

References

Chakravarti A et al. Cytomegalovirus infection: An Indian perspective. Indian J Med Microbiol 2009;.27: 3 11.

Chakravarty A et al. The seroepidemiological study on cytomegalovirus in women of child bearing age with special reference to pregnancy and maternal fetal transmission. Indian J Pathol Microbiol 2005; 48: 518 21.

Turbadkar D et al. Seroprevalence of torch infection in bad obstetric history. Indian J Med Microbiol 2003;.21: 108 10.

Mustakangas P et al. Human cytomegalovirus seroprevalence in three socioeconomically different urban areas during the first trimester: A population based cohort study. Int J Epidemiol 2000; 29: 587 91.

Kapil A, Broors S. Primary CMV infection in pregnant and non pregnant women. Indian J Med Microbiol 1992; 10: 53 5.

Sunanda N et al. Seroprevalence of cytomegalovirus specific IgM antibodies in pregnant women: A preliminary study. Indian J Med Microbiol 1994; 12: 65 7.

Stagno S et al. Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome. JAMA 1986; 256: 1904 8.

Khayyam N et al. Seroprevalence of TORCH infection in patients attending a tertiary care hospital with Bad Obstetric History. Int J Med Sc Edu 2017; 4: 393-9.

Shrivastava G et al. Seroprevalance of toxoplasma, rubella, CMV and HSV infection in pregnant women in central India. International J Health System and Disaster Management 2014, 4: 166-9.

Tamer GS et al. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clin Invest Med 2009; 32: E43 7.

Singh MP et al. Congenital rubella and cytomegalovirus infection in and around chandigarh. Indian J pathol microbial 2009; 52: 46-8.

Kumar M et al. Seroprevalence of CMV in antenatal women. J Marine Med Society 2017; 19: 51-4.

Colugnati FA et al. Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis 2007; 7: 71.

Staras SA et al. Seroprevalence of cytomegalovirus infection in the United States,1988 1994. Clin Infect Dis 2006; 43 : 1143 51.

Munro SC et al. Diagnosis of and screening for cytomegalovirus infection in pregnant women. J Clin Microbiol 2005; 43: 4713 8.

Cevrioglu AS et al. Toxoplasma, cytomegalovirus, rubella, hepatitis B and hepatitis C seropositivity rates in pregnant women who live in Afyon region. Med J Kocatepe 2004; 5: 49 53.

Ocak S et al. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scan J Infect Dis 2007; 39: 231 4.

Cvetkovich T. Cytomegalovirus infetions. In Pediatric Clinical Advisor 2nd ed.; Elsevier Inc. Lynn C. Garfunkel , Jeffrey M. Kaczorowski, Cynthia Christy, 2007.

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Published

17-10-2024

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