Formulation, Characterization, and Evaluation of Neomycin Sulphate Emulgel Incorporating Tea Tree Oil for Treatment of Bacterial Skin Infections
Keywords:
Neomycin Sulphate, Tea Tree Oil, Emulgel, Incorporation MethodAbstract
Background: Skin infection caused by bacteria is common and can be range from mild to severe. It includes topical treatment of antibiotics such as neomycin sulphate. However increasing the antibacterial properties the tea tree oil is used for the skin infection
Aim: The research specifically concerns with the development of a unique Emulgel system containing Neomycin Sulphate and Tea Tree Oil for the treatment of bacterial skin infections.
Methods: Emulgel of Neomycin Sulphate were prepared using Carbopol 934, Liquid Paraffin, Tea Tree Oil, Span 20, Tween 20, Propylene Glycol, Methyl Paraben, Propyl Paraben and Triethanolamine in different ratio by incorporation method. Every Emulgel formulation underwent testing on a range of characteristics, including physical inspection, pH measurement, rheological studies, spreadability, Zeta potential, SEM, TEM, in vitro investigation, and stability research.
Results: The Neomycin Sulphate Emulgel prepared with tea tree oil and the various formulations are presented by the help of Incorporation method and the better formulations are given F4.The formulations are given better viscosity, pH and in vitro study was given in the result and discussion.
Conclusion: The developed Neomycin Sulphate Emulgel with Tea Tree Oil shows as an effective topical treatment for bacterial skin infections, offering enhanced antibacterial activity by increasing the concentration of Tea Tree Oil in the Emulgel formulation.
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