Study of Analgesic Effect of Aqueous and Methanolic Extracts of Dry Powder of Zingiber Officinale in Wistar Rats.
DOI:
https://doi.org/10.53555/ejac.v19i1.1095Keywords:
.Abstract
Background
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly used for pain relief but often lead to adverse effects including gastrointestinal, renal and hepatic complications. Ginger widely used in traditional medicine, exhibits potential analgesic, anti-inflammatory and hepatoprotective properties. However, its efficacy in modern analgesic applications is not well-documented. Objective
To investigate the analgesic effects of aqueous and methanolic extracts of dry powder of Zingiber officinale (Z. officinale) in an experimental rat model. To compare analgesic activity of both extracts with that of standard drug.
Materials and methods
The study was conducted after animal ethics committee approval. Animals were divided into six groups. Control group received 0.2ml NS IP while test groups received aspirin (150mg/kg) , Aqueous extract of dry powder of Z. officinale (100 and 200mg/kg) , Methanolic extract of dry powder of Z. officinale (100 and 200 mg/kg). Rat tail flick method was used to investigate analgesic activity of Ginger.
Results
Both aqueous and methanolic extracts showed significant analgesic activity when compared with control.
Conclusion
Aqueous and methanolic extracts of dry powder of Z. officinale extracts show promising analgesic effects in rats.
Ginger extracts may offer a safer alternative or adjuvant to NSAIDs, particularly for chronic pain management.
References
Robbins SL, Kumar V, Cotran RS: Robbins and Cotran pathologic basis of disease. Robbins and Cotran . Robbins (ed): Elsevier, Philadelphia; 2010.
Becker DE: Pain management in adult dental patients: the art and science of successful regimens . PPAD. 1996, 8:1-6.
Hall JE, Hall ME: Textbook of Medical Physiology E-Book . Guyton and Hall (ed): Elsevier, Canada; 2020.
Oxenham D: Davidson’s Principles and Practice of Medicine. Penman, Ian D (ed): Elsevier, London; 2023.
Fields HL, Martin JB: Harrison's Principles of Internal Medicine . Longo, Dan (ed): McGraw-Hill Companies, Harvard; 2011.
Elhwuegi AS, Hassan KM: The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice. Libyan Journal of Medicine. 2012, 7:1. 10.3402/ljm.v7i0.17251 7. Shirooye P, Mokaberinejad R, Ara L, Hamzeloo-Moghadam M: Volatile constituents of ginger oil prepared according to Iranian traditional medicine and conventional method: a comparative study. African Journal of Traditional, Complementary and Alternative Medicines. 2016, 13:68-73. 10.21010/ajtcam.v13i6.11
Zadeh JB, Kor NM: Physiological and pharmaceutical effects of Ginger (Zingiber officinale Roscoe) valuable medicinal plant. Eur. J. Exp. Biol. 2014, 4:87-90.
Zahmatkash M, Vafaeenasab MR: Comparing analgesic effects of a topical herbal mixed medicine with salicylate in patients with knee osteoarthritis. Journal of Biological Sciences. 2011, 14:715-719. 10.3923/pjbs.2011.715.719
Koçak İ, Yücepur C, Gökler O: Is Ginger Effective in Reducing Post-tonsillectomy Morbidity? A Prospective Randomised Clinical Trial. Clinical and experimental otorhinolaryngology. 2018, 11:65. 10.21053/ceo.2017.00374
Kravchenko I, Eberle L, Nesterkina M, Kobernik A: Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale). J J Herbmed Pharmacol. 2019, 8:126-32. 10.15171/jhp.2019.20 12. Medhi B, Prakash A: Practical Manual of Experimental and Clinical Pharmacology . Medhi B (ed): Jaypee Brothers Medical Publishers, New Delhi; 2017. https://books.google.co.in/books.
Penna SC, Medeiros MV, Aimbire FS, Faria-Neto HC, Sertie JA, Lopes-Martins RA: Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomedicine. 2003, 10:381-385. 10.1078/0944-7113-00271
Shafeeqa I, Muhammad M, Mahmood S, et al.: A Critical Review On Pharmaceutical And Medicinal Importance Of Ginger. ACTA SCIENTIFIC NUTRITIONAL HEALTH. 2019, 3:78-82.
Dewi AR, Nur’aini I, Bahri IS, Afifah HN, Fattah A, Tunjung WA: Antihyperuricemic activity of ginger flower (Etlingera elatior Jack.) extract in beef broth-induced hyperuricemic rats (Rattus norvegicus). AIP. 2016, 1755:1. 10.1063/1.4958573
Roufogalis BD: Zingiber officinale (Ginger): a future outlook on its potential in prevention and treatment of diabetes and prediabetic states. New J. Sci. 2014, 1:674-684. 10.1155/2014/674684
Jolad SD, Lantz RC, Chen GJ, Bates RB, Timmermann BN : Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. Phytochem. 2005, 1:1614-1635. 10.1016/j.phytochem.2005.05.007
Srivastava KC, Mustafa T: Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders . Med Hypotheses. 1992, 39:342-8. 10.1016/0306-9877(92)90059-L
Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sankawa U: Inhibition of prostaglandin and leukotriene biosynthesisbygingerolsanddiarylheptanoids.ChemPharmBull.1992,40:387-391. 10.1248/cpb.40.387 20. Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC: Effect of ginger constit-uentsand synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem. 2001, 29:156-163. 10.1006/bioo.2001.1208 21. Tripathi S, Bruch D, Kittur DS: Ginger extract inhibits LPS induced macrophage activation and function . BMC Complement Altern Med. 2008, 8:1. 10.1186/1472-6882-8-1
Sepahvand R, Esmaeili-Mahani S, Arzi A, Rasoulian B, Abbasnejad M: Ginger (Zingiber officinale Roscoe) elicits antinociceptive properties and potentiates morphine-induced analgesia in the rat radiant heat tail flicktest.Journalofmedicinalfood.2010,1:1397-1401. 10.1089/jmf.2010.1043
Raji Y, Udoh US, Oluwadara OO, Akinsomisoye OS, Awobajo O: Anti-flammatory and analgesic properties of the rhizome extract of zingiber officinale. Afr. J. Biomed. 2002, 5:3.
Ojewole JA: Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytotherapy Research: An International Journal. 2006, 20:764-772. 10.1002/ptr.1952
Pakale PV, Khanwelkar CC, Jadhav SA: Study of anti-inflammatory activity of aqueous and methanolic extracts of fresh rhizome of Zingiber Officinale in Wistar rats. IJHS. 2022, 6:3. 10.53730/ijhs.v6nS3.5982
Pakale PV, Khanwelkar CC, Jadhav SA: Study of anti-inflammatory activity of aqueous and methanolic extracts of dry powder of zingiber officinale (SUNTH) in Wistar rats. IJHS. 2022, 6:3. 10.53730/ijhs.v6nS3.6521