Formulation and In vitro Evaluation of Mucoadhesive Buccal Tablets of Naproxen
Keywords:
Direct compression method, Naproxen, Carbopol, Sodium alginate, Chitosan, HPMC-K4M.Abstract
The objective of this study is to develop and evaluate mucoadhesive buccal tablets containing naproxen. Naproxen is a drug with a long half-life of 12-17 hours, making it suitable for formulation into mucoadhesive buccal tablets. These tablets offer rapid and complete absorption from the gastrointestinal tract, providing a high bioavailability of 95%. The formulation of naproxen mucoadhesive buccal tablets was achieved using a direct compression technique. Various polymers such as sodium alginate, carbopol, and chitosan were incorporated to investigate their impact on key parameters including drug content, in- vitro swelling studies, and in-vitro disintegration. Compatibility studies were conducted using FTIR and DSC methods. The prepared mucoadhesive buccal tablets were subjected to extensive evaluation tests. The optimized formulation showcased promising results with regards to in-vitro swelling studies (3.10±1.76), in-vitro disintegration (238.63±3.89), and drug content (98.95±0.026). These tablets were further evaluated for thickness, hardness, friability, weight variation, surface pH, drug content, and disintegration time. The release exponent for the formulation indicated super case II transport with a cumulative drug release of 97.87%.
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