Quantification of Drugs by Proton NMR Incorporated Internal Standard Method

Abstract

Quantitative Proton NMR (qNMR) by using internal standard method is reported for quantification of
drugs. 1, 4-Bis-Trimethylsilanyl-benzene is used as an internal standard for quantification of some
commonly used drugs. It resulted in good quantitative estimation, and complies less than 1% with
HPLC. An effort towards substantial advantageous application of quantitative NMR is reported.