Voltammetric Behaviour of Esomeprazole at Screen Printed Carbon Electrode and its Determination in Capsule Dosage Form

Abstract

The anodic voltammetric behavior of esomeprazole (ESO) was explored at screen printed carbon
electrode (SPCE) in phosphate buffer (PB) solutions over the pH range (2.0–11.0) using cyclic and
differential-pulse voltammetry (CV; DPV). The oxidation of ESO was shown to be irreversible and
diffusion-adsorption controlled driven process. Under optimized conditions, the DPV peak currents
were in a linear relationship to ESO concentrations in the range of 1.0×10-6-1.0×10-4 mol L-1 with a
detection limit of 3.5×10-8 mol L-1. The DPV was successfully employed for the determination of ESO
in capsules. The results were compared with those obtained by the spectrophotometric method. No
difference was found statistically. The voltammetric procedure was successfully also applied for rapid
analysis of ESO in stability studies without interference from the degradation products.