Simultaneous Estimation of Ramipril and Telmisartan in Tablet Dosage Form by Spectrophotometry

Abstract

Two simple, accurate, sensitive and specific methods are described for the simultaneous
determination of Ramipril and Telmisartan in binary mixture. The method based on UVspectrophotometric determination of two drugs, Method A is by using multicomponant method. It
involves absorbance measurement at 205.0 nm(λmax of Ramipril) and 291.0 nm (λmax of
Telmisartan) in 0.2M H2SO4;. Beer’s law is obeyed in the concentration range of 5-40 μg mL-1 for
Ramipril and 2-20 μg mL-1 for Telmisartan. Method B is graphical absorbance method which is
based on measurement of absorbance of Ramipril and Telmisartan at 222.0nm (iso-absorptive
point of Ramipril and Telmisartan) and 291.0 nm (λmax of Telmisartan) Both these methods have
been successively applied to pharmaceutical formulation and were validated according to ICH
guidelines.