Novel Reagent for the Spectrophotometric Determination of Ranitidine Hydrochloride

Abstract

A simple method is presented for the determination of ranitidine hydrochloride (RNH). The method is
based on the reaction of RNH with sodium periodate in acidic medium to liberate iodine. The liberated
iodine then bleaches the dye crystal violet (CV). The dye shows absorption maximum at 600 nm. The
calibration graph is found to be linear over the range 400.00-500.00 µg mL-1. The molar absorptivity
and sandell’s sensitivity values are found to be 1.98×103 Lmol-1cm-1 and 0.17 µgcm-2 respectively. The
proposed method is compared with the earlier spectrophotometric methods for the determination of
ranitidine hydrochloride. The method is successfully applied for the determination of ranitidine
hydrochloride in pharmaceutical preparations.