Indirect Electrothermal Atomization Atomic Absorption Spectrometric Determination of the Drug Desferrioxamine in Some Pharmaceutical Preparations Using Vanadium (V) as a Mediating Element

Abstract

A method has been developed for the determination of the drug Desferrioxamine (DFOM) in some
pharmaceuticals using indirect electrothermal atomic absorption spectrometry (ETAAS) supplied with
zirconium-coated graphite tube and vanadium (V) as a mediating metal. V (V) forms a chelate
complex with DFOM at pH range 1-1.5 which could be extracted with benzyl alcohol under certain
experimental conditions .Aliquots of the extracts are injected into the coated graphite furnace and the
atomic absorption signals are measured. A standard calibration graph was constructed and from which
several parameters and figures of merit were found, such as: linear range (0.5-19 μg mL –1) of DFOM,
relative standard deviation (1.44-1.68%); limit of detection (0.12 μg mL –1) sensitivity. (424.2 pg),
recovery %( 101.57± 0.147) and relative error (1.57%). The mole ratio method has been used to
determine the structure of chelate DFOM: V (V) and found to be 1:1. The developed procedure is
applied to analyze desferrioxamine in several commercially available pharmaceuticals using direct and
standard additions methods and results are comparable. All statistical calculations are implemented via
a Minitab software version 11