Determination of Methamphetamine by GC-Mass based on Molecularly Imprinted Solid-phase Used 2-hydroxy Ethyl Methacrylate as Functional Monomer

Abstract

A novel method characterized by high sensitivity, low cost and high stability was
developed. This method based on a molecularly imprinted polymer(MIP) using a functional
monomer which is 2-vinylpyridine (2-VP) and 2-hydroxyethyl methacrylate (2-HEMA),
suitable cross-linker and the template which is MAMP to fabricate a monolithic solid-phase
micro extraction (SPME) fiber. A polymer was also prepared without selective binding sites
this was referred to as a non-imprinted polymer (NIP). (SPME) with gas chromatography
and mass spectrometry (GC/MS); all these analytical methods used to extraction, preconcentration and selective determination of methamphetamine (MAMP) and its
derivatives. Firmness, stability and duration of the fabricated fiber give it its fundamental
and indispensable role in SPME.The samples were collected from methamphetamine
suspected abuser donate provided from the medico legal Directorate (Baghdad,
Iraq).Monitoring of the analytes was performed using a (GC MS) and using UV-vis and
Scanning electron microscopy (SEM) and FTIR. The relative standard deviations ) RSD%)
for five Patients repeated experiments for three measurements are range of (at 30-60 ppm
of MAMP) is (1.20-3.61) %. The relative recoveries obtained for MAMP in spiked human
urine samples are in the range of (93.63-99.71).