Naproxen Selective Membrane Sensor based on Molecularly Imprinted Polymer and Its Application to Pharmaceutical Analysis

Abstract

Liquid electrodes of polymers imprinted with naproxen(NPX)was constructed
using precipitation polymerization. The molecularly imprinted (MIP) and non imprinted
(NIP) polymers were synthesized using NPX as a template. In the polymerization process,
acrylamide (AM) was used as monomer ethylene glycol dimethacrylate (EGDMA) as a
cross-linker and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted
membranes and the non-imprinted membranes were prepared using acetophenone(AOPH)
and di octylphathalate(DOP)as plasticizers in PVC matrix. The slopes and detection limits
of the liquid electrodes ranged from -19.4 – -21.37 mV/decade and 4.0 x 10-5 – 3.0 x 10-5
M, respectively and their response time was about 1 minute. The Liquid electrodes were
filled with 0. 1 M standard solution of drug and their response was stable in a pH range
from 1.0 to 11.0 and with good selectivity for over several species. The developed
electrodes were successfully applied for the analyte determination in preparation
pharmaceutical sample without any time consuming pretreatment steps