Micellar Studies of Local Anticonvulsant Gabapentin in Aqueous Electrolyte Solution

Abstract

Specific conductivity of aqueous electrolyte solution of anticonvulsant gabapentin (2-[1-
(aminomethyl)cyclohexyl]ethanoicacid) has been determined in the temperature range of 303-
338 K. The critical micelle concentrations (cmc), ionization degree () and the counterion
binding of the micelle (, were estimated from the dependence of specific conductivity on
concentration. Thermodynamic parameters, such as standard Gibbs free energy (G
o
), enthalpy
(H
o
) and entropy (S
o
) of micellization, were estimated by the mass action model.