Comparison of Infusion and Bolus Injections of Phenylephrine on Hemodynamic Stability during Cardiopulmonary Bypass and their Effects on Bicarbonate and Lactate Blood Level

Abstract

During open cardiac surgery that the heart should be suspended, for preventing
damage of other tissues and organs, vasopressors drugs have been used for
maintenance of blood pressure. The aim of this study was the comparison of infusion
and bolus injections of phenylephrine on hemodynamic stability during
cardiopulmonary bypass and their effects on bicarbonate and lactate blood level. In
this randomized double-blind clinical trail, 88 patients who were candidate for onpump coronary artery bypass grafting, were considered and then divided into the
infusion and bolus groups. In the beginning and at the end of study, the blood pressure
and laboratorial variables was recorded and finally analyzed by SPSS software.
According to the obtained information, out of 88 examined patients, 52.2% of them
were received phenylephrine in bolus regimen while 47.8% were received
phenylephrine in infusion regimen. The mean age of patients in the bolus and infusion
groups was 56.59 ± 19.5 and 59.2 ± 10.16 years, respectively. The results show that
there were not statistically significant differences in mean values of the MAP, PH, HCO3
and lactate between two groups. The results show that the infusion injection of
phenylephrine has no advantage than bolus injection on hemodynamic stability during
cardiac pulmonary bypass, and on the bicarbonate and lactate blood level.