Preparation of Selective Sensors for Cyproheptadine Hydrochloride based on Molecularly Imprinted Polymer used N, N-Diethylaminoethyl Methacrylate as Functional Monomer

Abstract

The research involved the preparation of four selective sensors for cyproheptadine hydrochloride using molecularly imprinted polymers (MIPs) method. The process of polymerization was used for preparation of MIP using cyproheptadine hydrochloride as the template with N, N-(diethylaminoethyl methacrylate) (NDMAT) as monomer, N, O-bismethacryloyl ethanol amide (NBMEA) as cross linker, and 2, 2-azobisisobutyronitrile (AIBN) as initiator. Preparation of membrane as sensors for electrode construction based on different plasticizers, di-isodecyl adipate (DIA), di-isobutylmaleate (DIBM), 2-nitrophenyldodecylether (NPDE) and 3-trimethyltrimellitata (TMTM). The selective sensors were tested and their susceptibility to the estimation of the cyproheptadine hydrochloride, the selectivity coefficients of inorganic ions, sugars, amino acids, and drugs were also studied. The experimental results showed that the best electrode was based on DIA and TMTM as plasticizers, displaying a linear range from1×10-1-3×10-4M and 1×10-1-2×10-4M with a Nernstian slope of 58.4 mV/decade and 55.8 mV/decade, correlation coefficient of 0.9998 and 0.9993. The detection limit was 3.3×10-5 M and 2.4×10-5, the lifetime was around 30 and 48 days respectively. The proposed electrodes were applied successfully to the determination of cyproheptagine in a pharmaceutical preparation.