Simultaneous Spectrophotometric Determination of Clopidogrel Bisulfate, Atorvastatin Calcium Trihydrate and Aspirin by Double Devisor Ratio Derivative Spectrometric Method

Abstract

This study uses two spectrophotometric simple, accurate and economic methods for the simultaneous determination of Clopidogrel Bisulfate(CLO), Atorvastatin Calcium Trihydrate (ATV) and Aspirin (ASP) in their pharmaceutical form. mhe first Method is th first ratio derivative and the second method is the second ratio derivative, double devisor. The analytical aftermaths for each drug in the presence of the two others were as follows; CLO in presence of ATV and ASP showed Rec% (92.857-101.635)% and, (95.492-103.174)% , RSD % (0.000-0.363)% and (0.092-1.856)%,while for ATV in presence of CLO and ASP were Rec % (95.034-104.484%) and (95.090-103.174)%, RSD% (0.010-0.853)% and (0.647-1.749)%, and for ASP in presence of CLO and ATV Rec% (95.103-103.997)% and (96.107-103.091)%, RSD % (0.129-0.797)% and (0.094-0.878)%for the two methods respectively. Applying the two methods for all the pre-mentioned drugs in their pharmaceutical forms was successful.